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Press Releases

September 27, 2013

Microelectrode Arrays for Pain Research and Drug Development

Large amounts of information on the cellular and molecular mechanisms involved in sensory processing in the peripheral nervous system have been gained in vitro using neurons isolated from dorsal root ganglia (DRG). Electrophysiological recordings from cultured DRG neurons were mainly obtained by the use of patch-clamp, an approach offering a level of throughput often incompatible with the objectives of the pharmaceutical industry.

Higher throughput electrophysiological approaches are possible by using automated patch-clamp, but its current design limits its use to cell lines or cells in suspension.

Dr. Cesare will also discuss some of the unique features of this approach, such as the possibility it offers to perform continuous or repeated non-invasive measurements, as this may be of great importance for the evaluation of substances involved in inflammation. Finally, he will demonstrate the possibility to combine MEA and microfluidics for developing novel assays to investigate synaptic activity in nociceptive circuits.

The 7th Annual Pain and Migraine Therapeutics Summit brings together the pharmaceutical, biotech, device and medical communities to learn about the latest advances in the treatment of various types of pain. Conference attendance is comprised of thought leaders from industry, the non-profit sector, academia, the medical community, government and investors. The event will take place in San Diego, CA on November 7 – 8, 2013 at the Embassy Suites San Diego Bay – Downtown. The 7th Annual Pain & Migraine Therapeutics Summit focuses on drug discovery, clinical development and commercialization and is widely considered North America’s premier conference covering the fields of pain research and drug development.

For more information on this event please visit: www.paintherapeuticsummit.com

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